Aleem Gangjee Selected Research

Reduced Folate Carrier Protein

1/2021	Folate transporter dynamics and therapy with classic and tumor-targeted antifolates.
1/2020	Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.
12/2019	Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
1/2018	Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores).
1/2017	Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates.
9/2015	6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.
4/2013	Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.
2/2010	Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.

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Aleem Gangjee Research Topics

Disease

68	Neoplasms (Cancer) 01/2022 - 04/2002
5	Infections 01/2019 - 11/2003
4	Neoplasm Metastasis (Metastasis) 04/2012 - 05/2008
3	Ovarian Epithelial Carcinoma 01/2022 - 01/2017
3	Breast Neoplasms (Breast Cancer) 01/2021 - 05/2015
3	Opportunistic Infections (Opportunistic Infection) 01/2018 - 06/2013
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018 - 12/2012
2	Malignant Mesothelioma 01/2018 - 04/2013
2	Glioma (Gliomas) 09/2017 - 07/2015
2	Malaria 09/2014 - 10/2013
1	Ovarian Neoplasms (Ovarian Cancer) 01/2022
1	Adenocarcinoma 01/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 01/2019
1	Glioblastoma (Glioblastoma Multiforme) 07/2015
1	Necrosis 05/2015
1	Bacterial Infections (Bacterial Infection) 09/2014
1	Parasitic Diseases (Parasitic Disease) 10/2013
1	Mesothelioma 12/2012
1	Psoriasis (Pustulosis Palmaris et Plantaris) 09/2012
1	Melanoma (Melanoma, Malignant) 05/2010
1	Toxoplasmosis 02/2010

Drug/Important Bio-Agent (IBA)

28	Folic Acid AntagonistsIBA 01/2022 - 05/2002
22	pyrimidineIBA 01/2022 - 04/2002
21	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022 - 05/2002
17	Proton-Coupled Folate TransporterIBA 01/2021 - 10/2010
12	purineIBA 01/2022 - 10/2010
10	Pharmaceutical PreparationsIBA 01/2020 - 07/2004
9	NucleotidesIBA 01/2022 - 12/2012
9	PyrimidinesIBA 12/2019 - 11/2003
8	CarbonIBA 12/2021 - 12/2004
8	Reduced Folate Carrier ProteinIBA 01/2021 - 02/2010
8	Pemetrexed (MTA)FDA Link 01/2021 - 12/2004
7	EnzymesIBA 01/2021 - 05/2002
7	glycinamide ribonucleotideIBA 01/2021 - 10/2011
7	Hydroxymethyl and Formyl TransferasesIBA 01/2021 - 10/2011
6	TubulinIBA 01/2021 - 07/2007
6	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 11/2020 - 11/2003
6	Biological ProductsIBA 01/2020 - 11/2003
5	Glutamic Acid (Glutamate)FDA Link 02/2012 - 05/2002
4	Methotrexate (Mexate)FDA LinkGeneric 01/2021 - 09/2005
4	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2017 - 07/2007
3	Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)IBA 11/2020 - 10/2019
3	Adenosine Triphosphate (ATP)IBA 11/2020 - 05/2015
3	SaltsIBA 11/2018 - 07/2014
3	Cytostatic AgentsIBA 01/2017 - 09/2005
3	Angiogenesis InhibitorsIBA 01/2017 - 02/2010
3	Thymidylate SynthaseIBA 09/2014 - 10/2013
3	folylpolyglutamate synthetaseIBA 02/2008 - 05/2002
2	Taxoids (Taxanes)IBA 01/2021 - 07/2011
2	ThiophenesIBA 01/2021 - 02/2010
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2021 - 07/2007
2	RibonucleotidesIBA 01/2021 - 01/2020
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 11/2020 - 10/2019
2	SulfurIBA 01/2020 - 03/2013
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2017 - 07/2015
2	Proteins (Proteins, Gene)FDA Link 05/2015 - 10/2012
2	Sunitinib (Sutent)FDA Link 07/2014 - 05/2014
2	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 04/2013 - 05/2010
2	Protons (Proton)IBA 04/2013 - 10/2010
2	Colchicine FDA LinkGeneric 11/2012 - 07/2007
2	EstersIBA 10/2011 - 02/2010
2	Antimitotic AgentsIBA 07/2011 - 07/2007
2	Antineoplastic Agents (Antineoplastics)IBA 09/2005 - 11/2003
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)IBA 01/2021
1	QuinazolinesIBA 01/2021
1	furanIBA 01/2021
1	S 6 (S-6)IBA 01/2020
1	Aligeron (AS 2)IBA 01/2020
1	AmidesIBA 12/2019
1	NAD (NADH)IBA 10/2019
1	FluorineIBA 10/2018
1	Amino Acids FDA Link 01/2018
1	Immunoglobulin G (IgG)IBA 09/2017
1	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 01/2017
1	Cisplatin (Platino)FDA LinkGeneric 01/2017
1	IndolesIBA 01/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2017
1	Temozolomide (Temodar)FDA LinkGeneric 07/2015
1	Bevacizumab (Avastin)FDA Link 07/2015
1	GuanineIBA 07/2015
1	TransferasesIBA 07/2015
1	HMGB1 Protein (HMG1)IBA 05/2015
1	DiaminesIBA 05/2015
1	indoleIBA 05/2015
1	Docetaxel (Taxotere)FDA Link 07/2014
1	combretastatinIBA 05/2014
1	AminopterinIBA 09/2012
1	orantinib (SU6668)IBA 04/2012
1	multidrug resistance-associated protein 1IBA 07/2011
1	Vinca AlkaloidsIBA 07/2011
1	SymportersIBA 10/2010
1	Cytotoxins (Cytolysins)IBA 02/2010
1	AcidsIBA 02/2010
1	Growth InhibitorsIBA 05/2009
1	Phosphotransferases (Kinase)IBA 05/2008
1	tyrosine receptor (receptor, tyrosine)IBA 05/2008

Therapy/Procedure

9	Therapeutics 01/2022 - 09/2005
7	Drug Therapy (Chemotherapy) 11/2020 - 05/2002